Gwajin ya nuna yawan adadin magungunan ammonium na quaternary a matsayin jiyya ga ƙwayoyin cuta da yawa, gami da coronaviruses: waɗannan suna aiki ta hanyar kashe murfin lipid mai kariya wanda ke lulluɓe ƙwayoyin cuta kamar SARS-CoV-2.Quaternary ammonium mahadi suna yadu shawarar kashe ƙwayoyin cuta kuma akwai sama da 350 kayayyakin a kan EPA ta List N: Disinfectants don amfani da SARS-CoV-2 (Karin Material. The disinfectant taro da lamba lokaci (hade da mahara ƙwayoyin cuta) ga da yawa daga cikin disinfecting. An ba da rahoton sunadarai a cikin jerin EPA kuma> 140 na iya kashe kwayar cutar a cikin 'yan mintuna kaɗan (18).
Wannan bayanin ya kai mu ga babban bincike na mahaɗan ammonium quaternary tare da aiki akan coronaviruses da yiwuwar gano sinadarai waɗanda aka riga aka gwada a asibitin kuma ana iya amfani da su azaman yuwuwar jiyya ga COVID-19.Ɗaya daga cikin magungunan kashe ƙwayoyin cuta waɗanda aka nuna suna lalata ƙwayoyin cuta (Ƙarin Kayan aiki) kuma ana amfani da su sosai a cikin samfuran kulawa na sirri shine cetylpyridinium chloride.Ana samun wannan fili mafi yawa a cikin wankin baki kuma FDA ta jera shi azaman Gabaɗaya Game da Safe (GRAS) wanda kuma ana amfani da shi azaman wakili na antimicrobial na nama da kayan kiwon kaji (har zuwa 1%).An yi amfani da Cetylpyridinium chloride a cikin gwaje-gwajen asibiti da yawa, gami da a matsayin magani ga cututtukan numfashi da ke tabbatar da amfani da shi azaman maganin rigakafi.Cetylpyridinium yana iya haɓaka rashin kunna ƙwayoyin cuta ta hanyar lalata capsid da kuma ta hanyar aikin lysosomotropic, wanda, kamar yadda aka tattauna a sama, ya zama ruwan dare ga mahaɗan ammonium quaternary.Wannan ya haifar da tambaya game da ko wasu magungunan da aka gano tare da aikin rigakafin cutar SARS-CoV-2 in vitro suna yin irin wannan, wato suna iya lalata kwayar cutar tare da taruwa a cikin lysosome ko endosomes kuma a ƙarshe suna toshe shigarwar hoto.Ƙarin binciken da aka buga ya nuna cewa za a iya rage wannan tasirin ta hanyar amfani da masu hana Cathepsin-L.
Cetylpyridinium chloride (CPC)
Haɗin ammonium na Quaternary tare da sanannun ayyukan coronavirus
| Kwayoyin halitta | Ayyukan antiviral | Makanikai | FDA ta amince | Amfani |
| Ammonium chloride | Murine coronavirus, hepatitis C, | Lysosomotropic | Ee | Amfani daban-daban ciki har da metabolism acidosis. |
| Cetylpyridinium chloride | mura, hepatitis B, poliovirus 1 | Manufa capsid kuma yana da lysosomotropic | Iya, GRAS | Maganin kashe kwayoyin cuta, wankin baki, gyambon tari, kayan kula da mutum, kayan tsaftacewa da sauransu. |
Lokacin aikawa: Agusta-03-2021